Record ID No. |
399 |
Author(s) |
Broberg A., Menkis A., Vasiliauskas R. , 2006 |
Affiliation |
Swedish University of Agricultural Sciences, Department of Chemistry, POB 7015, SE-75007 Uppsala, Sweden |
Title |
Kutznerides 1-4, depsipeptides from the actinomycete Kutzneria sp 744 inhabiting mycorrhizal roots of Picea abies seedlings |
Source. Vol.(no):Page |
Journal of natural products. 69(1): 97-102p. |
Categories |
Mycorrhiza General |
Subjects |
Biochemistry |
Sub-subjects |
Hormones |
Host |
Picea abies |
Organism |
Kutzneria sp, actinomycete |
Country |
Sweden, Europe |
Abstracts |
Bioassay-guided fractionation of culture supernatants of the actinomycete Kutzneria sp. 744 resulted in the isolation of four new depsipeptides (1-4). Structure analysis revealed the general structure: cyclo[2-(I-methylcyclopropyl)-D-glycine-(2S,3aR,8aS)-6,7-dichloro-3a-hyd roxy-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid-3-hydroxy-D-glutamic acid-o-methyl-L-serine-L-piperazie acid-(S)-2-hydroxy-3,3-dimethylbutanoic acid]. The 3-hydroxy-D-glutamic acid was present as its threo-isomer in 1 and 2 and as its erythro-isomer in 3 and 4. The piperazic acid was modified to its (R)-4-chloro analogue in 2 and to its C-5/N unsaturated analogue in 4. Compounds 1-4 displayed moderate spore germination inhibiting activity against several common root-rotting fungi. |